Organosilicon Reagents

Our organosilicon and related silicon reagents have many practical synthesis applications, as well as manufacturing applications in the production of adhesives, sealants, automotive lubricants, computer chips, and dry-cleaning solvents to healthcare products such as skin care products, small molecule drugs, and contacts.

Due to drawbacks inherent in transition-metal-catalyzed cross-coupling of organometallic reagents with organic halides, organosilicon reagents have emerged as suitable alternatives. The lack of toxicity, high chemical stability, and low molecular weight of organosilane compounds make them ideal for use as nucleophilic partners in cross-coupling with organic halides and pseudohalides. The conditions for the construction of new C–C bonds via palladium-catalyzed cross-coupling of organosilanes are mild but require a nucleophilic promoter to provide high yields of the desired cross-coupling products. The byproducts of the cross-coupling reaction are polysiloxanes, which can be easily removed by conventional methods such as chromatography (silica gel or reverse-phase) or distillation. We are proud to offer a large variety of silicon compounds that are highly competent coupling partners for the palladium-catalyzed cross-coupling reaction to make your breakthroughs feel closer than ever.